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The more pragmatic question is whether peptides can complement biologic therapy, potentially improving outcomes or allowing dose reduction

Regarding MAPK1 and MAPK3, studies have reported that they are involved in BRCA through several approaches, including the activation of cell cycle-related proteins and inhibition of antiapoptotic proteins by MAPK1/MAPK3 phosphorylation, and regulation of cytoskeletal proteins to promote migration 36

2013;2(1): e22620

Briefly, brains of 3MST knockout mice or the wild-type mice were removed at the postnatal day 1 or 2 and submerged in the ice-cold Leiboritzs L-15 medium (Life Technologies, Waltham Massachusetts, USA)